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KMID : 0378120030300020237
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Chungnam Medical Journal
2003 Volume.30 No. 2 p.237 ~ p.243
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Histologic Changes of Kidney and Ureter after Partial and Complete Unilateral Ureteral Obstruction in the Rabbit
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Kim Sang-Hyun
Kim Yong-Woong
Yuk Seung-Mo
Han Dong-Seok
Roh An-Sik
Lim Jae-Sung
Kim Hong-Sik
Na Yong-Gil
Sul Chong-Koo
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Abstract
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This study was designed to clarify histologic changes in the experimental rabbit kidney and ureter after unilateral partial or complete ureteral obstruction.
A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, the partial obstruction followed by 4 weeks, the complete obstruction followed by 2 weeks, and the complete obstruction followed by 4 weeks. The normal control group was consisted of 5 adult white rabbits.
The kidneys and ureters for light microscopy were fixed in 10% neutral formalin, embedded in paraffin and stained with hematoxylin and eosin.
Abnormal histologic fingings showed in ipsilateral kidney and ureter of all subgroups(such as dilatation of uriniferous tubule, focal necrosis and desquamation of epithelium, interstitial fibrosis, glomerular congestion, widening of Bowman’s space, dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis and interstitial inflammation).
These findings were most severe in the group of the complete-obstructed ureter for 4 weeks. No significant changes showed in contralateral ureter of all subgroups.
The degree of obstruction was severe and period of obstruction was long, the histological changes in ipsilateral side were severe. Despite of changes in ipsilateral side no abnormal findings showed in contralateral side.
We suggest that long term experimental investigation of histologic changes in ipsilateral side and compensatory changes in contralateral side have to be studied.
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KEYWORD
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Ureteral obstruction, Hydronephrosis, Histologic change
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